aloxistatin

CHEBI:101381 ·resolve ·ANTIVIRAL ·EXACT SEEDED

An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:23990 CHEBI:23990
CHEBI:25018 CHEBI:25018
CHEBI:29347 CHEBI:29347
CHEBI:32955 CHEBI:32955

Chemical structure

Computed structure properties
Molecular formula	C17H30N2O5
Charge	0
Average mass	342.436 Da
Monoisotopic mass	342.21547 Da
Source	ChEBI
InChIKey	SRVFFFJZQVENJC-IHRRRGAJSA-N

SMILES

CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C

InChI

InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

Also called

aloxistatina (INN)— chebi
aloxistatine (INN)— chebi
aloxistatinum (INN)— chebi
ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate (EXACT_SYNONYM)— chebi
E 64d (EXACT_SYNONYM)— chebi
E-64d (EXACT_SYNONYM)— chebi
E64d (EXACT_SYNONYM)— chebi
Ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate (EXACT_SYNONYM)— chebi
Loxistatin (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:88321-09-9
reaxys:5354546

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:101381`	aloxistatin	`antibioticmech:chebi-bb168add9f`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.