anolignan B

CHEBI:65411 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A lignan that consists of buta-1,3-diene substituted by 4-hydroxybenzyl groups at positions 2 and 3. It is isolated from the ground stems of Anogeissus acuminata and exhibits anti-HIV activity by inhibiting HIV-1 reverse transcriptase enzyme. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25036 CHEBI:25036
CHEBI:33853 CHEBI:33853

Chemical structure

Computed structure properties
Molecular formula	C18H18O2
Charge	0
Average mass	266.34 Da
Monoisotopic mass	266.13068 Da
Source	ChEBI
InChIKey	VVKZAZVVUAFFGF-UHFFFAOYSA-N

SMILES

C=C(Cc1ccc(O)cc1)C(=C)Cc1ccc(O)cc1

InChI

InChI=1S/C18H18O2/c1-13(11-15-3-7-17(19)8-4-15)14(2)12-16-5-9-18(20)10-6-16/h3-10,19-20H,1-2,11-12H2

Also called

4-[3-(4-hydroxybenzyl)-2-methylidenebut-3-en-1-yl]phenol (EXACT_SYNONYM)— chebi
2,3-bis-(4-hydroxybenzyl)-1,3-butadiene (EXACT_SYNONYM)— chebi
4,4'-(2,3-bis(methylene)-1,4-butanediyl)bisphenol (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:158081-98-2
reaxys:7812590

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:53756 CHEBI:53756

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:65411`	anolignan B	`antibioticmech:chebi-c4117c34bd`	2026-08-30

Mechanism summary

Mode of action: VIRAL_POLYMERASE_INHIBITION microbial target — Assigned from ChEBI role CHEBI:53756 (HIV-1 reverse transcriptase inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.