AntibioticMech

baricitinib

CHEBI:95341 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:18379 CHEBI:18379
• CHEBI:26410 CHEBI:26410
• CHEBI:35358 CHEBI:35358
• CHEBI:38670 CHEBI:38670
• CHEBI:38777 CHEBI:38777

Chemical structure

Computed structure properties

Molecular formula	C16H17N7O2S
Charge	0
Average mass	371.426 Da
Monoisotopic mass	371.11644 Da
Source	ChEBI
InChIKey	XUZMWHLSFXCVMG-UHFFFAOYSA-N

SMILES

CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4nccc34)cn2)C1

InChI

InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

Also called

• Olumiant (BRAND_NAME)— chebi
• baricitinibum (INN)— chebi
• {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile (EXACT_SYNONYM)— chebi
• 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile (EXACT_SYNONYM)— chebi
• 2-(3-(4-(3H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile (EXACT_SYNONYM)— chebi
• INCB 028050 (EXACT_SYNONYM)— chebi
• INCB-028050 (EXACT_SYNONYM)— chebi
• INCB028050 (EXACT_SYNONYM)— chebi
• LY 3009104 (EXACT_SYNONYM)— chebi
• LY-3009104 (EXACT_SYNONYM)— chebi
• LY3009104 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:1187594-09-7
• chemspider:26373084
• drugbank:DB11817
• hmdb:HMDB0248873
• kegg.drug:D10308
• lincs.smallmolecule:LSM-6709
• pdb-ccd:3JW
• wikipedia.en:Baricitinib

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:22587 CHEBI:22587

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:95341	baricitinib	antibioticmech:chebi-e1b62d6a71	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.