carnosic acid

CHEBI:65585 ·resolve ·ANTIVIRAL ·EXACT SEEDED

An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:25384 CHEBI:25384
CHEBI:33566 CHEBI:33566
CHEBI:36762 CHEBI:36762
CHEBI:38032 CHEBI:38032

Chemical structure

Computed structure properties
Molecular formula	C20H28O4
Charge	0
Average mass	332.44 Da
Monoisotopic mass	332.19876 Da
Source	ChEBI
InChIKey	QRYRORQUOLYVBU-VBKZILBWSA-N

SMILES

[H][C@@]12CCc3cc(C(C)C)c(O)c(O)c3[C@@]1(C(=O)O)CCCC2(C)C

InChI

InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1

Also called

11,12-dihydroxyabieta-8,11,13-trien-20-oic acid (EXACT_SYNONYM)— chebi
(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-(propan-2-yl)-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid (EXACT_SYNONYM)— chebi
11,12-dihydroxy-13-isopropylpodocarpa-8,11,13-trien-17-oic acid (EXACT_SYNONYM)— chebi
Salvin (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:3650-09-7
metacyc.compound:CPD-18103
reaxys:2707918
wikipedia.en:Carnosic_acid

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:35660 CHEBI:35660

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:65585`	carnosic acid	`antibioticmech:chebi-8bfba62826`	2026-08-30

Mechanism summary

Mode of action: VIRAL_PROTEASE_INHIBITION microbial target — Assigned from ChEBI role CHEBI:35660 (HIV protease inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.