AntibioticMech

CHIR-265

CHEBI:91451 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:22715 CHEBI:22715
• CHEBI:24780 CHEBI:24780
• CHEBI:26421 CHEBI:26421
• CHEBI:35618 CHEBI:35618
• CHEBI:37143 CHEBI:37143
• CHEBI:48975 CHEBI:48975
• CHEBI:83565 CHEBI:83565

Chemical structure

Computed structure properties

Molecular formula	C24H16F6N6O
Charge	0
Average mass	518.421 Da
Monoisotopic mass	518.12898 Da
Source	ChEBI
InChIKey	YABJJWZLRMPFSI-UHFFFAOYSA-N

SMILES

Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)n4)c3)ccc21

InChI

InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)

Also called

• 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine (EXACT_SYNONYM)— chebi
• CHIR 265 (EXACT_SYNONYM)— chebi
• CHIR265 (EXACT_SYNONYM)— chebi
• RAF 265 (EXACT_SYNONYM)— chebi
• RAF-265 (EXACT_SYNONYM)— chebi
• RAF265 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:927880-90-8
• lincs.smallmolecule:LSM-1207
• patent:WO2011044072
• pdb-ccd:55J

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:22587 CHEBI:22587

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:91451	CHIR-265	antibioticmech:chebi-87c8d0ce35	2026-08-30

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.