AntibioticMech

clomipramine hydrochloride

CHEBI:3755 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:36807 CHEBI:36807

Chemical structure

Computed structure properties

Molecular formula	C19H23ClN2.HCl
Charge	0
Average mass	351.321 Da
Monoisotopic mass	350.13165 Da
Source	ChEBI
InChIKey	WIMWMKZEIBHDTH-UHFFFAOYSA-N

SMILES

CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21.Cl

InChI

InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

Also called

• Anafranil (BRAND_NAME)— chebi
• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride (EXACT_SYNONYM)— chebi
• 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-aminium chloride (EXACT_SYNONYM)— chebi
• 3-chloroimipramine hydrochloride (EXACT_SYNONYM)— chebi
• chloroimipramine monohydrochloride (EXACT_SYNONYM)— chebi
• clomipramine HCl (EXACT_SYNONYM)— chebi
• clomipramine monohydrochloride (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:17321-77-6
• drugbank:DB01242
• kegg.drug:D00811
• reaxys:4168494
• vsdb:1812

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:3755	clomipramine hydrochloride	antibioticmech:chebi-e8856719f3	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.