decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone

CHEBI:156289 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chloroacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:36683 CHEBI:36683
CHEBI:48030 CHEBI:48030

Chemical structure

Computed structure properties
Molecular formula	C34H66ClN11O5
Charge	0
Average mass	744.427 Da
Monoisotopic mass	743.49369 Da
Source	ChEBI
InChIKey	NHBJTTGFHCHQHS-VZTVMPNDSA-N

SMILES

CCCCCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)CCl)C(C)C

InChI

InChI=1S/C34H66ClN11O5/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26-,29-/m0/s1

Also called

N2-decanoyl-L-arginyl-L-valyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-lysinamide (EXACT_SYNONYM)— chebi
N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide (EXACT_SYNONYM)— chebi
dec-RVKR-cmk (EXACT_SYNONYM)— chebi
decanoyl-Arg-Val-Lys-Arg-chloromethylketone (EXACT_SYNONYM)— chebi
decanoyl-RVKR-CMK (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:150113-99-8

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:22587 CHEBI:22587

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:156289`	decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone	`antibioticmech:chebi-5b8a0c5e47`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.