AntibioticMech

elvitegravir

CHEBI:72289 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is used in combination therapy for the treatment of HIV-1 infection. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:23765 CHEBI:23765
• CHEBI:26512 CHEBI:26512
• CHEBI:35618 CHEBI:35618
• CHEBI:37143 CHEBI:37143
• CHEBI:83403 CHEBI:83403

Chemical structure

Computed structure properties

Molecular formula	C23H23ClFNO5
Charge	0
Average mass	447.89 Da
Monoisotopic mass	447.12488 Da
Source	ChEBI
InChIKey	JUZYLCPPVHEVSV-LJQANCHMSA-N

SMILES

COc1cc2c(cc1Cc1cccc(Cl)c1F)c(=O)c(C(=O)O)cn2[C@H](CO)C(C)C

InChI

InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1

Also called

• elvitegravirum (INN)— chebi
• elvitégravir (INN)— chebi
• 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (EXACT_SYNONYM)— chebi
• GS 9137 (EXACT_SYNONYM)— chebi
• GS-9137 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:697761-98-1
• drugcentral:4300
• kegg.drug:D06677
• lincs.smallmolecule:LSM-5647
• patent:WO2009089263
• patent:WO2010137032
• patent:WO2011004389
• reaxys:10609264
• wikipedia.en:Elvitegravir

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:67268 CHEBI:67268

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:72289	elvitegravir	antibioticmech:chebi-5b109c28b2	2026-08-30

Mechanism summary

Mode of action

VIRAL_INTEGRASE_INHIBITION microbial target — Assigned from ChEBI role CHEBI:67268 (HIV-1 integrase inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.