favipiravir-RTP

CHEBI:170009 ·resolve ·ANTIVIRAL ·EXACT REVIEWED

A nuceloside analogue in which the nucleobase is favipiravir. It is a RNA-dependent RNA polymerase inhibitor which exhibits anti-influenza and anti-coronaviral activities. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:140324
Label unavailable CHEBI:167376
Label unavailable CHEBI:37143
Label unavailable CHEBI:60783
Label unavailable CHEBI:62894

Chemical structure

Computed structure properties
Molecular formula	C10H15FN3O15P3
Charge	0
Average mass	529.156 Da
Monoisotopic mass	528.97 Da
Source	ChEBI
InChIKey	UUKPXXBDUCDZDA-KAFVXXCXSA-N

SMILES

NC(=O)c1nc(F)cn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c1=O

InChI

InChI=1S/C10H15FN3O15P3/c11-4-1-14(9(18)5(13-4)8(12)17)10-7(16)6(15)3(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h1,3,6-7,10,15-16H,2H2,(H2,12,17)(H,22,23)(H,24,25)(H2,19,20,21)/t3-,6-,7-,10-/m1/s1

Also called

6-fluoro-4-[5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-β-D-ribofuranosyl]-3-oxo-3,4-dihydropyrazine-2-carboxamide (EXACT_SYNONYM)— chebi
6-fluoro-3,4-dihydro-4-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-β-D-ribofuranosyl)-3-oxo-2-pyrazinecarboxamide (EXACT_SYNONYM)— chebi
T-705 RTP (EXACT_SYNONYM)— chebi
T-705 ribosyl triphosphate (EXACT_SYNONYM)— chebi
T-705-4-ribofuranosyl-5'-triphosphate (EXACT_SYNONYM)— chebi
T-705RTP (EXACT_SYNONYM)— chebi
favipiravir riboside triphosphate (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

anticoronaviral agent CHEBI:149553
antiviral drug CHEBI:36044

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:170009`	favipiravir-RTP	`antibioticmech:chebi-1a84f4f03d`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

SARS-CoV-2 RNA-dependent RNA polymerase catalytic site VIRAL_PROTEIN DIRECT_BINDING_TARGET

A 2.5-A cryo-EM structure resolved favipiravir-RTP with template-primer-bound RdRp; polymerase assays supported weak incorporation and suppression of RNA replication. Evidence status: PRIMARY_EVIDENCE. Source: PRIMARY_LITERATURE 2021-02 (retrieved 2026-09-02).

Organism-specific examples
Protein	Gene	Organism	Entry
Replicase polyprotein 1ab `UniProtKB:P0DTD1` SARS-CoV-2 replicase polyprotein 1ab encoding the nsp12 RNA-dependent RNA polymerase catalytic subunit resolved with favipiravir-RTP by cryo-EM (PMID:33526596, PDB 7CTT).	rep	Severe acute respiratory syndrome coronavirus 2 `NCBITaxon:2697049`	REVIEWED

PMID:33526596 (Primary cryo-EM structure and polymerase-activity study of the exact triphosphate metabolite.)

Mechanism summary

Mode of action: VIRAL_POLYMERASE_INHIBITION microbial target — CURATOR: PMID:33526596 resolved favipiravir-RTP at the catalytic site of the SARS-CoV-2 RNA-dependent RNA polymerase by 2.5-A cryo-EM and showed weak incorporation plus suppression of RNA replication in polymerase assays. The evidence concerns the active triphosphate metabolite represented by this record, not parent favipiravir.

Record-level evidence

PMID:33526596 (Primary exact-metabolite structure and polymerase-mechanism study.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
REVIEWED 2026-09-02 · codex · LLM-assisted
Verified the exact triphosphate identity, structure, and antiviral class; curator-confirmed viral polymerase inhibition and added the direct SARS-CoV-2 RdRp catalytic-site target.
CURATED_UNIPROT_PROTEIN_EXAMPLES 2026-10-18 · antigravity · LLM-assisted
Added curated SARS-CoV-2 replicase polyprotein 1ab (P0DTD1) UniProtKB protein example on the PRIMARY_LITERATURE SARS-CoV-2 RNA-dependent RNA polymerase catalytic site molecular target.

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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