favipiravir

CHEBI:134722 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of pyrazines that is pyrazine substituted by aminocarbonyl, hydroxy and fluoro groups at positions 2, 3 and 6, respectively. It is an anti-viral agent that inhibits RNA-dependent RNA polymerase of several RNA viruses and is approved for the treatment of influenza in Japan. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:140324 CHEBI:140324
CHEBI:37143 CHEBI:37143
CHEBI:71633 CHEBI:71633

Chemical structure

Computed structure properties
Molecular formula	C5H4FN3O2
Charge	0
Average mass	157.104 Da
Monoisotopic mass	157.02875 Da
Source	ChEBI
InChIKey	ZCGNOVWYSGBHAU-UHFFFAOYSA-N

SMILES

NC(=O)c1nc(F)cnc1O

InChI

InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)

Also called

Areplivir (BRAND_NAME)— chebi
Avifavir (BRAND_NAME)— chebi
Avigan (BRAND_NAME)— chebi
Favilavir (BRAND_NAME)— chebi
Favipira (BRAND_NAME)— chebi
favipiravirum (INN)— chebi
6-fluoro-3-hydroxypyrazine-2-carboxamide (EXACT_SYNONYM)— chebi
6-fluoro-3-hydroxy-2-pyrazinecarboxamide (EXACT_SYNONYM)— chebi
T 705 (EXACT_SYNONYM)— chebi
T-705 (EXACT_SYNONYM)— chebi
T705 (EXACT_SYNONYM)— chebi
fapilavir (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:259793-96-9
chemspider:431002
drugbank:DB12466
drugcentral:4887
kegg.drug:D09537
reaxys:9697246
wikipedia.en:Favipiravir

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553
CHEBI:36044 CHEBI:36044

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:134722`	favipiravir	`antibioticmech:chebi-90624c9d31`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

Replicase polyprotein 1ab VIRAL_PROTEIN MEASURED_TARGET_ASSOCIATION

BindingDB quantitative measurement in the named target organism; source assay descriptions and identifiers are retained per measurement. Evidence status: PRIMARY_EVIDENCE. Source: BINDINGDB 2026-09 (retrieved 2026-08-31).

Severe acute respiratory syndrome coronavirus 2 NCBITaxon:2697049

Quantitative measurements
Type	Reported value	Assay	BindingDB IDs	Reference
EC50	61880 nM	No assay is provided This is a review article.	`RSID 868949` `assay 8918_1` `monomer 429507`	`PMID:32852058`

Organism-specific examples
Protein	Gene	Organism	Entry
Replicase polyprotein 1ab `UniProtKB:P0DTD1`	—	Severe acute respiratory syndrome coronavirus 2	REVIEWED

PMID:32852058 (BindingDB literature-curated quantitative target measurement; source value, assay text, reaction-set ID, and target organism retained.)

Mechanism summary

Mode of action: VIRAL_POLYMERASE_INHIBITION microbial target — Assigned from ChEBI role CHEBI:170010 (EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.