ginkgetin

CHEBI:5353 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24698 CHEBI:24698
CHEBI:25241 CHEBI:25241
CHEBI:36820 CHEBI:36820
CHEBI:50128 CHEBI:50128

Chemical structure

Computed structure properties
Molecular formula	C32H22O10
Charge	0
Average mass	566.518 Da
Monoisotopic mass	566.1213 Da
Source	ChEBI
InChIKey	AIFCFBUSLAEIBR-UHFFFAOYSA-N

SMILES

COc1cc(O)c2c(=O)cc(-c3ccc(OC)c(-c4c(O)cc(O)c5c(=O)cc(-c6ccc(O)cc6)oc45)c3)oc2c1

InChI

InChI=1S/C32H22O10/c1-39-18-10-20(34)30-23(37)13-27(41-28(30)11-18)16-5-8-25(40-2)19(9-16)29-21(35)12-22(36)31-24(38)14-26(42-32(29)31)15-3-6-17(33)7-4-15/h3-14,33-36H,1-2H3

Also called

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one (EXACT_SYNONYM)— chebi
4''',5,5'',7''-tetrahydroxy-4',7-dimethoxy-(3'→8'')-biflavone (EXACT_SYNONYM)— chebi
5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (EXACT_SYNONYM)— chebi
Amentoflavone 7,4'-dimethyl ether (EXACT_SYNONYM)— chebi
Ginkgetin (EXACT_SYNONYM)— chebi
amentoflavone 7,4'-dimethyl ether (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:481-46-9
kegg.compound:C10048
knapsack:C00001044
lincs.smallmolecule:LSM-42758
lipidmaps:LMPK12040003
reaxys:381052

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:64953 CHEBI:64953

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:5353`	ginkgetin	`antibioticmech:chebi-1b6891c3ef`	2026-08-30

Molecular targets

The molecular entity or process this compound acts on. Each target carries evidence — this is a mechanistic claim, not a classification.

Replicase polyprotein 1ab VIRAL_PROTEIN MEASURED_TARGET_ASSOCIATION

BindingDB quantitative measurement in the named target organism; source assay descriptions and identifiers are retained per measurement. Evidence status: PRIMARY_EVIDENCE. Source: BINDINGDB 2026-09 (retrieved 2026-08-31).

Severe acute respiratory syndrome coronavirus NCBITaxon:2901879

Quantitative measurements
Type	Reported value	Assay	BindingDB IDs	Reference
IC50	32700 nM	No assay is provided This is a review article.	`RSID 868614` `assay 8917_1` `monomer 429271`	`PMID:26878082`
IC50	32000 nM	Various Assay This is a review article. Please point to the original journal.	`RSID 1074231` `assay 10079_1` `monomer 429271`	`PMID:34798775`
KI	30200 nM	Various Assay This is a review article. Please point to the original journal.	`RSID 1074232` `assay 10079_1` `monomer 429271`	`PMID:34798775`

Organism-specific examples
Protein	Gene	Organism	Entry
Replicase polyprotein 1ab `UniProtKB:P0C6X7`	—	Severe acute respiratory syndrome coronavirus	REVIEWED

PMID:26878082 (BindingDB literature-curated quantitative target measurement; source value, assay text, reaction-set ID, and target organism retained.)
PMID:34798775 (BindingDB literature-curated quantitative target measurement; source value, assay text, reaction-set ID, and target organism retained.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.