hydroxyzine

CHEBI:5818 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:46789 CHEBI:46789
CHEBI:46845 CHEBI:46845
CHEBI:83403 CHEBI:83403

Chemical structure

Computed structure properties
Molecular formula	C21H27ClN2O2
Charge	0
Average mass	374.912 Da
Monoisotopic mass	374.17611 Da
Source	ChEBI
InChIKey	ZQDWXGKKHFNSQK-UHFFFAOYSA-N

SMILES

OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

InChI

InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

Also called

hidroxizina (INN)— chebi
hydroxyzinum (INN)— chebi
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol (EXACT_SYNONYM)— chebi
Hychotine (EXACT_SYNONYM)— chebi
Hydroxine (EXACT_SYNONYM)— chebi
Hydroxizine (EXACT_SYNONYM)— chebi
Hydroxizinum (EXACT_SYNONYM)— chebi
Hydroxycine (EXACT_SYNONYM)— chebi
Hydroxyzin (EXACT_SYNONYM)— chebi
Hydroxyzine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:68-88-2
drugbank:DB00557
drugcentral:1400
hmdb:HMDB0014697
kegg.compound:C07045
kegg.drug:D08054
lincs.smallmolecule:LSM-5103
patent:US2899436
reaxys:321392
vsdb:2977
wikipedia.en:Hydroxyzine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:5818`	hydroxyzine	`antibioticmech:chebi-fdcc11d94b`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.