mefuparib hydrochloride

CHEBI:167899 ·resolve ·ANTIVIRAL ·EXACT SEEDED

The hydrochloride salt of mefuparib. It is a potent poly(ADP-ribose) polymerase inhibitor which exhibits strong anticancer activity and also inhibits SARS-CoV-2 in cell culture. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:36807

Chemical structure

Computed structure properties
Molecular formula	C17H15FN2O2.HCl
Charge	0
Average mass	334.778 Da
Monoisotopic mass	334.08843 Da
Source	ChEBI
InChIKey	GPFWTAVHQKERKY-UHFFFAOYSA-N

SMILES

CNCc1ccc(-c2cc3cc(F)cc(C(N)=O)c3o2)cc1.Cl

InChI

InChI=1S/C17H15FN2O2.ClH/c1-20-9-10-2-4-11(5-3-10)15-7-12-6-13(18)8-14(17(19)21)16(12)22-15;/h2-8,20H,9H2,1H3,(H2,19,21);1H

Also called

5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide hydrochloride (EXACT_SYNONYM)— chebi
5-fluoro-2-(4-((methylamino)methyl)phenyl)benzofuran-7-carboxamide hydrochloride (EXACT_SYNONYM)— chebi
5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide—hydrogen chloride (EXACT_SYNONYM)— chebi
CVL 218 (EXACT_SYNONYM)— chebi
CVL-218 (EXACT_SYNONYM)— chebi
CVL218 (EXACT_SYNONYM)— chebi
[4-(7-carbamoyl-5-fluoro-1-benzofuran-2-yl)phenyl]-N-methylmethanaminium chloride (EXACT_SYNONYM)— chebi
mefuparib HCl (EXACT_SYNONYM)— chebi
mefuparib monohydrochloride (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

cas:1449746-00-2

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

anticoronaviral agent CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:167899`	mefuparib hydrochloride	`antibioticmech:chebi-5fbec2fe8d`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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