MST-312

CHEBI:95003 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of benzamides that results from the formal condensation of the two amino groups of benzene-1,3-diamine with the carboxylic acid groups of two molar equivalents of 2,3-dihydroxybenzoic acid. It is telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay) and exhibits antineoplastic activity. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:140325 CHEBI:140325
CHEBI:22702 CHEBI:22702
CHEBI:33566 CHEBI:33566

Chemical structure

Computed structure properties
Molecular formula	C20H16N2O6
Charge	0
Average mass	380.356 Da
Monoisotopic mass	380.10084 Da
Source	ChEBI
InChIKey	MIQUEZGHEJGPJB-UHFFFAOYSA-N

SMILES

O=C(Nc1cccc(NC(=O)c2cccc(O)c2O)c1)c1cccc(O)c1O

InChI

InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

Also called

N,N'-benzene-1,3-diylbis(2,3-dihydroxybenzamide) (EXACT_SYNONYM)— chebi
MST 312 (EXACT_SYNONYM)— chebi
MST312 (EXACT_SYNONYM)— chebi
N,N'-(1,3-phenylene)bis(2,3-dihydroxybenzamide) (EXACT_SYNONYM)— chebi
N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamine (EXACT_SYNONYM)— chebi
N-[3-[[(2,3-dihydroxyphenyl)-oxomethyl]amino]phenyl]-2,3-dihydroxybenzamide (EXACT_SYNONYM)— chebi
telomerase inhibitor IX (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:368449-04-1
lincs.smallmolecule:LSM-6230

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:59897 CHEBI:59897

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:95003`	MST-312	`antibioticmech:chebi-b6a5e7b03e`	2026-08-30

Mechanism summary

Mode of action: VIRAL_POLYMERASE_INHIBITION host shared target — Assigned from ChEBI role CHEBI:59897 (EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.