AntibioticMech

mycophenolic acid

CHEBI:168396 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:25384 CHEBI:25384
• CHEBI:33853 CHEBI:33853
• CHEBI:37581 CHEBI:37581
• CHEBI:38831 CHEBI:38831

Chemical structure

Computed structure properties

Molecular formula	C17H20O6
Charge	0
Average mass	320.341 Da
Monoisotopic mass	320.12599 Da
Source	ChEBI
InChIKey	HPNSFSBZBAHARI-RUDMXATFSA-N

SMILES

COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2

InChI

InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

Also called

• acide mycophenolique (INN)— chebi
• acido micofenolico (INN)— chebi
• acidum mycophenolicum (INN)— chebi
• (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid (EXACT_SYNONYM)— chebi
• (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid (EXACT_SYNONYM)— chebi
• Micofenolico acido (EXACT_SYNONYM)— chebi
• Mycophenolate (EXACT_SYNONYM)— chebi
• Mycophenolsäure (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:24280-93-1
• drugbank:DB01024
• drugcentral:1860
• kegg.drug:D05096
• patent:US4753935
• pdb-ccd:MOA
• reaxys:318158
• wikipedia.en:Mycophenolic_acid

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:149553 CHEBI:149553
• CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:168396	mycophenolic acid	antibioticmech:chebi-d2a5e263f3	2026-08-30

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.