N2-methylharmine

CHEBI:66005 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of β-carbolines that is 9H-β-carboline substituted by a methoxy group at position 7 and methyl groups at positions 1 and 2. It is a semisynthetic derivative of harmine and has been shown to exhibit significant anti-HIV activity. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:35618
Label unavailable CHEBI:60834
Label unavailable CHEBI:72588

Chemical structure

Computed structure properties
Molecular formula	C14H14N2O
Charge	0
Average mass	226.279 Da
Monoisotopic mass	226.11061 Da
Source	ChEBI
InChIKey	SNPOLGTUMADPOR-UHFFFAOYSA-N

SMILES

COc1ccc2c3ccn(C)c(C)c-3nc2c1

InChI

InChI=1S/C14H14N2O/c1-9-14-12(6-7-16(9)2)11-5-4-10(17-3)8-13(11)15-14/h4-8H,1-3H3

Also called

7-methoxy-1,2-dimethyl-2H-β-carboline (EXACT_SYNONYM)— chebi
7-methoxy-1,2-dimethyl-2H-pyrido[3,4-b]indole (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

cas:6519-18-2
reaxys:15521

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

anti-HIV agent CHEBI:64946

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:66005`	N2-methylharmine	`antibioticmech:chebi-75dc625ca2`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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