omacetaxine mepesuccinate

CHEBI:71019 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26878 CHEBI:26878
CHEBI:38164 CHEBI:38164
CHEBI:38481 CHEBI:38481
CHEBI:47985 CHEBI:47985

Chemical structure

Computed structure properties
Molecular formula	C29H39NO9
Charge	0
Average mass	545.629 Da
Monoisotopic mass	545.26248 Da
Source	ChEBI
InChIKey	HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES

[H][C@]12c3cc4c(cc3CCN3CCC[C@@]31C=C(OC)[C@H]2OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)OCO4

InChI

InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

Also called

Synribo (BRAND_NAME)— chebi
mepesuccinato de omacetaxina (INN)— chebi
mépésuccinate d'omacétaxine (INN)— chebi
omacetaxini mepesuccinas (INN)— chebi
(2'R,3S,4S,5R)-(−)-homoharringtonine (EXACT_SYNONYM)— chebi
(−)-homoharringtonine (EXACT_SYNONYM)— chebi
CGX-635 (EXACT_SYNONYM)— chebi
Homoharringtonine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:26833-87-4
drugcentral:4677
kegg.drug:D08956
lincs.smallmolecule:LSM-3716
patent:US2010240887
patent:WO2007089878
pdb-ccd:HMT
reaxys:5687925
wikipedia.en:Omacetaxine_mepesuccinate

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:71019`	omacetaxine mepesuccinate	`antibioticmech:chebi-9f22c7510c`	2026-08-30

Mechanism summary

Mode of action: PROTEIN_SYNTHESIS_INHIBITION host shared target — Assigned from ChEBI role CHEBI:48001 (protein synthesis inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status: APPROVED

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.