PB28

CHEBI:189648 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (σ2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:26144 CHEBI:26144
CHEBI:35618 CHEBI:35618
CHEBI:36786 CHEBI:36786

Chemical structure

Computed structure properties
Molecular formula	C24H38N2O
Charge	0
Average mass	370.581 Da
Monoisotopic mass	370.29841 Da
Source	ChEBI
InChIKey	PHRCDWVPTULQMT-UHFFFAOYSA-N

SMILES

COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1

InChI

InChI=1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3

Also called

1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (EXACT_SYNONYM)— chebi
1-(3-(5-methoxytetralin-1-yl)propyl)-4-cyclohexylpiperazine (EXACT_SYNONYM)— chebi
1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine (EXACT_SYNONYM)— chebi
1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperazine (EXACT_SYNONYM)— chebi
PB 28 (EXACT_SYNONYM)— chebi
PB-28 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:172906-90-0
chemspider:8649746
wikipedia.en:PB-28

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:189648`	PB28	`antibioticmech:chebi-c0b7a35c75`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.