AntibioticMech

plerixafor

CHEBI:125354 ·resolve ·ANTIVIRAL ·EXACT SEEDED

An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:22712 CHEBI:22712
• CHEBI:37411 CHEBI:37411
• CHEBI:37949 CHEBI:37949
• CHEBI:50995 CHEBI:50995
• CHEBI:50996 CHEBI:50996
• CHEBI:52898 CHEBI:52898

Chemical structure

Computed structure properties

Molecular formula	C28H54N8
Charge	0
Average mass	502.796 Da
Monoisotopic mass	502.44714 Da
Source	ChEBI
InChIKey	YIQPUIGJQJDJOS-UHFFFAOYSA-N

SMILES

c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1

InChI

InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2

Also called

• Mozobil (BRAND_NAME)— chebi
• plerixaforum (INN)— chebi
• plérixafor (INN)— chebi
• 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane) (EXACT_SYNONYM)— chebi
• 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane) (EXACT_SYNONYM)— chebi
• 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane (EXACT_SYNONYM)— chebi
• AMD 3100 (EXACT_SYNONYM)— chebi
• AMD-3100 (EXACT_SYNONYM)— chebi
• AMD3100 (EXACT_SYNONYM)— chebi
• JKL 169 (EXACT_SYNONYM)— chebi
• JM3100 (EXACT_SYNONYM)— chebi
• SDZ SID 791 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:110078-46-1
• drugbank:DB06809
• drugcentral:4410
• hmdb:HMDB0015681
• kegg.drug:D08971
• lincs.smallmolecule:LSM-36826
• wikipedia.en:Plerixafor

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:64946 CHEBI:64946

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:125354	plerixafor	antibioticmech:chebi-d8f34e69af	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.