promethazine

CHEBI:8461 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:32876 CHEBI:32876
CHEBI:38093 CHEBI:38093

Chemical structure

Computed structure properties
Molecular formula	C17H20N2S
Charge	0
Average mass	284.428 Da
Monoisotopic mass	284.13472 Da
Source	ChEBI
InChIKey	PWWVAXIEGOYWEE-UHFFFAOYSA-N

SMILES

CC(CN1c2ccccc2Sc2ccccc21)N(C)C

InChI

InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

Also called

prometazina (INN)— chebi
promethazinum (INN)— chebi
prométhazine (INN)— chebi
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine (EXACT_SYNONYM)— chebi
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine (EXACT_SYNONYM)— chebi
10-(2-Dimethylaminopropyl)phenothiazine (EXACT_SYNONYM)— chebi
10-[2-(dimethylamino)propyl]phenothiazine (EXACT_SYNONYM)— chebi
N,N,α-trimethyl-10H-phenothiazine-10-ethanamine (EXACT_SYNONYM)— chebi
N-(2'-dimethylamino-2'-methyl)ethylphenothiazine (EXACT_SYNONYM)— chebi
Promethazine (EXACT_SYNONYM)— chebi
proazamine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:60-87-7
drugbank:DB01069
drugcentral:2286
gmelin:337077
hmdb:HMDB0015202
kegg.compound:C07404
kegg.drug:D00494
lincs.smallmolecule:LSM-4440
patent:US2530451
patent:US2607773
reaxys:88554
wikipedia.en:Promethazine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:8461`	promethazine	`antibioticmech:chebi-0f98d9cd82`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.