AntibioticMech

ribavirin

CHEBI:63580 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:140324 CHEBI:140324
• CHEBI:29347 CHEBI:29347
• CHEBI:62733 CHEBI:62733
• CHEBI:63594 CHEBI:63594

Chemical structure

Computed structure properties

Molecular formula	C8H12N4O5
Charge	0
Average mass	244.207 Da
Monoisotopic mass	244.08077 Da
Source	ChEBI
InChIKey	IWUCXVSUMQZMFG-AFCXAGJDSA-N

SMILES

NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1

InChI

InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

Also called

• ribavirina (INN)— chebi
• ribavirine (INN)— chebi
• ribavirinum (INN)— chebi
• 1-(β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide (EXACT_SYNONYM)— chebi
• 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (EXACT_SYNONYM)— chebi
• 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide (EXACT_SYNONYM)— chebi
• RBV (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:36791-04-5
• drugbank:DB00811
• drugcentral:2373
• kegg.drug:D00423
• lincs.smallmolecule:LSM-5701
• reaxys:892462
• wikipedia.en:Ribavirin

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:149553 CHEBI:149553
• CHEBI:22587 CHEBI:22587
• CHEBI:59897 CHEBI:59897

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:63580	ribavirin	antibioticmech:chebi-00b0c11612	2026-08-30

Mechanism summary

Mode of action

VIRAL_POLYMERASE_INHIBITION host shared target — Assigned from ChEBI role CHEBI:59897 (EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.