telbivudine

CHEBI:63624 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:19255 CHEBI:19255

Chemical structure

Computed structure properties
Molecular formula	C10H14N2O5
Charge	0
Average mass	242.231 Da
Monoisotopic mass	242.09027 Da
Source	ChEBI
InChIKey	IQFYYKKMVGJFEH-CSMHCCOUSA-N

SMILES

Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)nc1=O

InChI

InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1

Also called

1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione (EXACT_SYNONYM)— chebi
1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil (EXACT_SYNONYM)— chebi
2'-Deoxy-L-thymidine (EXACT_SYNONYM)— chebi
Beta-l-thymidine (EXACT_SYNONYM)— chebi
Epavudine (EXACT_SYNONYM)— chebi
L-DT (EXACT_SYNONYM)— chebi
L-deoxythymidine (EXACT_SYNONYM)— chebi
L-thymidine (EXACT_SYNONYM)— chebi
LDT (EXACT_SYNONYM)— chebi
β-L-2'-deoxythymidine (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:3424-98-4
drugbank:DB01265
drugcentral:4220
kegg.drug:D06675
reaxys:754297
wikipedia.en:Telbivudine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:36044 CHEBI:36044
CHEBI:59897 CHEBI:59897

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:63624`	telbivudine	`antibioticmech:chebi-38fd43bd7f`	2026-08-30

Mechanism summary

Mode of action: VIRAL_POLYMERASE_INHIBITION host shared target — Assigned from ChEBI role CHEBI:59897 (EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor). ChEBI asserts the role on the compound. The target it names is one the host has too, so the mechanism is true but is not evidence of selectivity — see mode_of_action_target_scope. Not a curator's mechanistic review.
Clinical status: APPROVED

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.