tioguanine

CHEBI:9555 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:20702

Chemical structure

Computed structure properties
Molecular formula	C5H5N5S
Charge	0
Average mass	167.197 Da
Monoisotopic mass	167.02657 Da
Source	ChEBI
InChIKey	WYWHKKSPHMUBEB-UHFFFAOYSA-N

SMILES

Nc1nc(=S)c2ncnc2n1

InChI

InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

Also called

tioguanina (INN)— chebi
tioguaninum (INN)— chebi
2-amino-1,9-dihydro-6H-purine-6-thione (EXACT_SYNONYM)— chebi
2-Amino 6MP (EXACT_SYNONYM)— chebi
2-Amino-1,7-dihydro-6H-purine-6-thione (EXACT_SYNONYM)— chebi
2-Amino-6-mercaptopurine (EXACT_SYNONYM)— chebi
2-Amino-6-merkaptopurin (EXACT_SYNONYM)— chebi
2-Amino-6-purinethiol (EXACT_SYNONYM)— chebi
2-Aminopurin-6-thiol (EXACT_SYNONYM)— chebi
2-Aminopurine-6(1H)-thione (EXACT_SYNONYM)— chebi
2-Aminopurine-6-thiol (EXACT_SYNONYM)— chebi
2-amino-1,9-dihydropurine-6-thione (EXACT_SYNONYM)— chebi
6-Mercapto-2-aminopurine (EXACT_SYNONYM)— chebi
6-Mercaptoguanine (EXACT_SYNONYM)— chebi
6-TG (EXACT_SYNONYM)— chebi
6-Thioguanine (EXACT_SYNONYM)— chebi
TG (EXACT_SYNONYM)— chebi
ThG (EXACT_SYNONYM)— chebi
Thioguanine (EXACT_SYNONYM)— chebi
Tioguanin (EXACT_SYNONYM)— chebi
6-thioguanine (RELATED_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

wikipedia.en:Thioguanine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

anticoronaviral agent CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:9555`	tioguanine	`antibioticmech:chebi-39c1d436bc`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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