AntibioticMech

trametinib

CHEBI:75998 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:22160 CHEBI:22160
• CHEBI:33860 CHEBI:33860
• CHEBI:36820 CHEBI:36820
• CHEBI:37142 CHEBI:37142
• CHEBI:37143 CHEBI:37143
• CHEBI:38932 CHEBI:38932
• CHEBI:51454 CHEBI:51454

Chemical structure

Computed structure properties

Molecular formula	C26H23FIN5O4
Charge	0
Average mass	615.403 Da
Monoisotopic mass	615.07788 Da
Source	ChEBI
InChIKey	LIRYPHYGHXZJBZ-UHFFFAOYSA-N

SMILES

CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1

InChI

InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

Also called

• trametinibum (INN)— chebi
• tramétinib (INN)— chebi
• N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide (EXACT_SYNONYM)— chebi
• GSK 1120212 (EXACT_SYNONYM)— chebi
• JTP 74057 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:871700-17-3
• chemspider:9881833
• drugbank:DB08911
• drugcentral:4802
• kegg.drug:D10175
• lincs.smallmolecule:LSM-1143
• patent:WO2005121142
• patent:WO2011038082
• patent:WO2011038085
• patent:WO2011047238
• reaxys:12497153
• wikipedia.en:Trametinib

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:149553 CHEBI:149553

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:75998	trametinib	antibioticmech:chebi-7d80535a6f	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.