AntibioticMech

trifluridine

CHEBI:75179 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis. — ChEBI

Classification

Strictly broader compounds or drug classes this molecule belongs to.

• CHEBI:19255 CHEBI:19255
• CHEBI:37143 CHEBI:37143
• CHEBI:60783 CHEBI:60783

Chemical structure

Computed structure properties

Molecular formula	C10H11F3N2O5
Charge	0
Average mass	296.201 Da
Monoisotopic mass	296.06201 Da
Source	ChEBI
InChIKey	VSQQQLOSPVPRAZ-RRKCRQDMSA-N

SMILES

O=c1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F

InChI

InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

Also called

• Viroptic (BRAND_NAME)— chebi
• trifluridina (INN)— chebi
• trifluridinum (INN)— chebi
• 2'-deoxy-5-(trifluoromethyl)uridine (EXACT_SYNONYM)— chebi
• 5-(Trifluoromethyl)deoxyuridine (EXACT_SYNONYM)— chebi
• 5-Trifluoromethyl-2-deoxyuridine (EXACT_SYNONYM)— chebi
• Trifluoromethyldeoxyuridine (EXACT_SYNONYM)— chebi
• Trifluorothymidine (EXACT_SYNONYM)— chebi
• trifluorothymine deoxyriboside (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

• cas:70-00-8
• drugbank:DB00432
• drugcentral:2743
• hmdb:HMDB0014576
• kegg.drug:D00391
• lincs.smallmolecule:LSM-5217
• reaxys:568095
• wikipedia.en:Trifluridine

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

• CHEBI:36044 CHEBI:36044

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
CHEBI	CHEBI:75179	trifluridine	antibioticmech:chebi-261a22a1ab	2026-08-30

Mechanism summary

Clinical status

APPROVED

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (CHEBI)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.