tyrphostin AG 1478

CHEBI:75404 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:35618 CHEBI:35618
CHEBI:38530 CHEBI:38530
CHEBI:83403 CHEBI:83403

Chemical structure

Computed structure properties
Molecular formula	C16H14ClN3O2
Charge	0
Average mass	315.76 Da
Monoisotopic mass	315.07745 Da
Source	ChEBI
InChIKey	GFNNBHLJANVSQV-UHFFFAOYSA-N

SMILES

COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC

InChI

InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

Also called

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine (EXACT_SYNONYM)— chebi
AG 1478 (EXACT_SYNONYM)— chebi
AG-1478 (EXACT_SYNONYM)— chebi
tyrphostin AG-1478 (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:170449-18-0
lincs.smallmolecule:LSM-1224
pdb-ccd:0TO
reaxys:7437034

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:22587 CHEBI:22587

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:75404`	tyrphostin AG 1478	`antibioticmech:chebi-48cc0bf0b4`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.