tyrphostin AG 1478

CHEBI:75404 ·resolve ·ANTIVIRAL ·EXACT SEEDED

A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:35618
Label unavailable CHEBI:38530
Label unavailable CHEBI:83403

Chemical structure

Computed structure properties
Molecular formula	C16H14ClN3O2
Charge	0
Average mass	315.76 Da
Monoisotopic mass	315.07745 Da
Source	ChEBI
InChIKey	GFNNBHLJANVSQV-UHFFFAOYSA-N

SMILES

COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC

InChI

InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

Also called

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine (EXACT_SYNONYM)— chebi
AG 1478 (EXACT_SYNONYM)— chebi
AG-1478 (EXACT_SYNONYM)— chebi
tyrphostin AG-1478 (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antiviral agent CHEBI:22587

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:75404`	tyrphostin AG 1478	`antibioticmech:chebi-48cc0bf0b4`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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