acriflavine

antibioticmech:aro-1fe0873afd ·BIOCIDE ·MINTED SEEDED

Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. Acriflavine is also used as treatment for external fungal infections of aquarium fish. — PMID:11566977

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

disinfecting agents and antisepticsARO:3005386

Strictly broader compounds or drug classes this molecule belongs to.

disinfecting agents and antiseptics ARO:3005386

Chemical structure

Computed structure properties
Molecular formula	C27H25ClN6
Charge	0
Average mass	469.0 Da
Monoisotopic mass	468.1829225 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	PEJLNXHANOHNSU-UHFFFAOYSA-N

SMILES

C[N+]1=C2C=C(C=CC2=CC3=C1C=C(C=C3)N)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.[Cl-]

InChI

InChI=1S/C14H13N3.C13H11N3.ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;1H

Also called

Acriflavin (EXACT_SYNONYM)— aro
Assiflavine (EXACT_SYNONYM)— aro
Bialflavina (EXACT_SYNONYM)— aro
Bioacridin (EXACT_SYNONYM)— aro
Bovoflavin (EXACT_SYNONYM)— aro
Buroflavin (EXACT_SYNONYM)— aro
Choliflavin (EXACT_SYNONYM)— aro
Euflavine (EXACT_SYNONYM)— aro
Pantonsiletten (EXACT_SYNONYM)— aro
Xanthacridinum (EXACT_SYNONYM)— aro

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
ARO	`ARO:0000045`	acriflavine	`antibioticmech:aro-1fe0873afd`	2026-08-30

Resistance mechanisms

19 source-backed resistance determinants or associations, with ARO grounding where reported. Grouped by reported mechanism type.

ANTIBIOTIC_EFFLUX 19

ANTIBIOTIC_EFFLUX
Determinant	ARO ID	Organism	Gene families	Evidence
Acinetobacter baumannii AmvA	ARO:3004577	not organism-specific	—	ARO:3004577 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance	ARO:3003374	not organism-specific	—	ARO:3003374 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MdtNOP	ARO:3004101	not organism-specific	—	ARO:3004101 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MexGHI-OpmD	ARO:3000799	not organism-specific	—	ARO:3000799 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MexHI-OpmD	ARO:3009153	not organism-specific	—	ARO:3009153 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MexPQ-OpmE	ARO:3003697	not organism-specific	—	ARO:3003697 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MexVW-OprM	ARO:3003029	not organism-specific	—	ARO:3003029 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
MexXY-OprM	ARO:3003032	not organism-specific	—	ARO:3003032 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
abeM	ARO:3000753	not organism-specific	—	ARO:3000753 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
acrB	ARO:3000216	not organism-specific	—	ARO:3000216 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
blt	ARO:3003006	not organism-specific	—	ARO:3003006 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
bmr	ARO:3003007	not organism-specific	—	ARO:3003007 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
cdeA	ARO:3003835	not organism-specific	—	ARO:3003835 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
emeA	ARO:3003551	not organism-specific	—	ARO:3003551 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
hmrM	ARO:3003953	not organism-specific	—	ARO:3003953 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
mdeA	ARO:3007011	not organism-specific	—	ARO:3007011 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
mdtM	ARO:3001214	not organism-specific	—	ARO:3001214 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
norA	ARO:3000391	not organism-specific	—	ARO:3000391 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)
sepA	ARO:3007012	not organism-specific	—	ARO:3007012 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:0000045 (acriflavine); database assertion, not a primary citation.)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (ARO)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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