hydrogen peroxide

CHEBI:16240 ·resolve ·BIOCIDE ·EXACT SEEDED

An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:24837 CHEBI:24837
CHEBI:26523 CHEBI:26523

Chemical structure

Computed structure properties
Molecular formula	H2O2
Charge	0
Average mass	34.014 Da
Monoisotopic mass	34.00548 Da
Source	ChEBI
InChIKey	MHAJPDPJQMAIIY-UHFFFAOYSA-N

SMILES

[H]OO[H]

InChI

InChI=1S/H2O2/c1-2/h1-2H

Also called

bis(hydridooxygen)(O—O) (EXACT_SYNONYM)— chebi
dihydrogen peroxide (EXACT_SYNONYM)— chebi
dihydrogen(peroxide) (EXACT_SYNONYM)— chebi
dioxidane (EXACT_SYNONYM)— chebi
H2O2 (EXACT_SYNONYM)— chebi
HOOH (EXACT_SYNONYM)— chebi
HYDROGEN PEROXIDE (EXACT_SYNONYM)— chebi
Hydrogen peroxide (EXACT_SYNONYM)— chebi
Oxydol (EXACT_SYNONYM)— chebi
[OH(OH)] (EXACT_SYNONYM)— chebi
dihydrogen dioxide (EXACT_SYNONYM)— chebi
perhydrol (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:7722-84-1
drugcentral:3281
gmelin:509
hmdb:HMDB0003125
kegg.compound:C00027
kegg.drug:D00008
metacyc.compound:HYDROGEN-PEROXIDE
molbase:932
pdb-ccd:PEO
ppdb:387
reaxys:3587191
wikipedia.en:Hydrogen_peroxide

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281
CHEBI:48219 CHEBI:48219

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:16240`	hydrogen peroxide	`antibioticmech:chebi-b4cb37a12a`	2026-08-30

Mechanism summary

Clinical status: APPROVED

Resistance mechanisms

6 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

UNKNOWN 6

UNKNOWN
Determinant	ARO ID	Organism	Gene families	Evidence
ATG9delta (deletion) associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum `NCBITaxon:5518` strain PH-1 `NCBITaxon:229533` `UniProtKB:I1S9X9` FGRAMPH1_01T26133 `PHIPO:0000632`	—	PMID:30044782 (PHI-base primary-literature antimicrobial interaction PHIG:264; joined to this record by exact ChEBI identifier.) Cell growth assay
Des1delta (deletion) associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Magnaporthe oryzae `NCBITaxon:318829` strain Guy11 `NCBITaxon:242507` `UniProtKB:G4N021` `PHIPO:0000632`	—	PMID:38056173 (PHI-base primary-literature antimicrobial interaction PHIG:10915; joined to this record by exact ChEBI identifier.) Cell growth assay
Hdf1delta (deletion) associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum `NCBITaxon:5518` strain PH-1 `NCBITaxon:229533` `UniProtKB:I1RCN2` `PHIPO:0000632`	—	PMID:21138346 (PHI-base primary-literature antimicrobial interaction PHIG:8901; joined to this record by exact ChEBI identifier.) Cell growth assay
Ndk1delta (deletion) associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum `NCBITaxon:5518` strain PH-1 `NCBITaxon:229533` `UniProtKB:I1RPK0` `PHIPO:0000632`	—	PMID:41277790 (PHI-base primary-literature antimicrobial interaction PHIG:10429; joined to this record by exact ChEBI identifier.) Cell growth assay
OS-2delta (deletion) associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Fusarium graminearum `NCBITaxon:5518` strain PH-1 `NCBITaxon:229533` `UniProtKB:P0C431` FGRAMPH1_01T26671 `PHIPO:0000632`	—	PMID:22591226 (PHI-base primary-literature antimicrobial interaction PHIG:7590; joined to this record by exact ChEBI identifier.) Cell growth assay
Ppe44+ (wild type) [Overexpression] associated with resistance to hydrogen peroxide This is a curated gene-alteration/chemical resistance association, not evidence for a specific biochemical resistance mechanism.	—	Mycobacterium tuberculosis `NCBITaxon:1773` strain H37Rv `NCBITaxon:83332` `UniProtKB:P9WHZ3` `PHIPO:0000632`	—	PMID:28743081 (PHI-base primary-literature antimicrobial interaction PHIG:11310; joined to this record by exact ChEBI identifier.) Macroscopic observation (quantitative observation)

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-02 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-03 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.