AS-186g

CHEBI:65446 ·resolve ·ANTIMICROBIAL_UNSPECIFIED ·EXACT SEEDED

A dibenzodioxonine isolated from the culture broth of Penicillium asperosporum that acts as an acyl-CoA:cholesterol acyltransferase inhibitor. It is one of the 8 possible diastereomers of AS-186c. However the exact stereochemistry of the compound is unknown. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:22726 CHEBI:22726
CHEBI:25000 CHEBI:25000
CHEBI:26195 CHEBI:26195
CHEBI:35618 CHEBI:35618
CHEBI:47622 CHEBI:47622
CHEBI:71155 CHEBI:71155

Chemical structure

Computed structure properties
Molecular formula	C43H46O12
Charge	0
Average mass	754.829 Da
Monoisotopic mass	754.29893 Da
Source	ChEBI
InChIKey	MQLUFEFCCDNPMA-UHFFFAOYSA-N

SMILES

COc1c(C(CC(C)C)OC(C)=O)ccc2c1C(=O)OC(c1cc(C)cc(O)c1C(=O)c1c(O)ccc(CC=C(C)C)c1O)C(O)c1cc(C)cc(O)c1O2

InChI

InChI=1S/C43H46O12/c1-20(2)9-10-25-11-13-29(45)35(37(25)48)39(50)34-27(16-22(5)18-30(34)46)42-38(49)28-17-23(6)19-31(47)40(28)54-32-14-12-26(33(15-21(3)4)53-24(7)44)41(52-8)36(32)43(51)55-42/h9,11-14,16-19,21,33,38,42,45-49H,10,15H2,1-8H3

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:65446`	AS-186g	`antibioticmech:chebi-f95a6414e7`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.