oxyphenbutazone

CHEBI:76258 ·resolve ·ANTIMICROBIAL_UNSPECIFIED ·EXACT SEEDED

A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

Label unavailable CHEBI:33853
Label unavailable CHEBI:38312

Chemical structure

Computed structure properties
Molecular formula	C19H20N2O3
Charge	0
Average mass	324.38 Da
Monoisotopic mass	324.14739 Da
Source	ChEBI
InChIKey	HFHZKZSRXITVMK-UHFFFAOYSA-N

SMILES

CCCCC1C(=O)N(c2ccccc2)N(c2ccc(O)cc2)C1=O

InChI

InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3

Also called

oxifenbutazona (INN)— chebi
oxyphenbutazonum (INN)— chebi
1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione (EXACT_SYNONYM)— chebi
1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine (EXACT_SYNONYM)— chebi
1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine (EXACT_SYNONYM)— chebi
3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene (EXACT_SYNONYM)— chebi
4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione (EXACT_SYNONYM)— chebi
4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione (EXACT_SYNONYM)— chebi
4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine (EXACT_SYNONYM)— chebi
4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione (EXACT_SYNONYM)— chebi
Hydroxyphenylbutazon (EXACT_SYNONYM)— chebi
Oxi-fenibutol (EXACT_SYNONYM)— chebi
Oxifenylbutazon (EXACT_SYNONYM)— chebi
Oxiphenbutazonum (EXACT_SYNONYM)— chebi
Oxyphenylbutazone (EXACT_SYNONYM)— chebi
p-Hydroxyphenylbutazone (EXACT_SYNONYM)— chebi
p-Oxyphenylbutazone (EXACT_SYNONYM)— chebi

Cross-references

Identifiers for this same structure in other resources. An accession that lands on two different structures in this corpus is withheld from both rather than shown here, since it names at most one of them.

Drug registries

Identifiers that name a drug rather than a structure. One of these can cover a parent compound, its salts and its stereoisomers, which this corpus keeps as separate records, so it is not an equivalence of structure.

Patents and articles

Documents about this compound. A patent covers a class and an article covers a topic; neither identifies a structure.

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

antimicrobial agent CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:76258`	oxyphenbutazone	`antibioticmech:chebi-25f84cf54d`	2026-08-30

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-09-10 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record (YAML).

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