sulfathiazole

CHEBI:9337 ·resolve ·ANTIMICROBIAL_UNSPECIFIED ·EXACT SEEDED

A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position. — ChEBI

Machine-generated and unreviewed. Identity, structure and cross-references come straight from ChEBI's and CARD's own data; no curator has signed off on this record yet.

Classification

Strictly broader compounds or drug classes this molecule belongs to.

CHEBI:35358 CHEBI:35358
CHEBI:38418 CHEBI:38418
CHEBI:48975 CHEBI:48975
CHEBI:87228 CHEBI:87228

Chemical structure

Computed structure properties
Molecular formula	C9H9N3O2S2
Charge	0
Average mass	255.324 Da
Monoisotopic mass	255.01362 Da
Source	ChEBI
InChIKey	JNMRHUJNCSQMMB-UHFFFAOYSA-N

SMILES

Nc1ccc(S(=O)(=O)Nc2nccs2)cc1

InChI

InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)

Also called

Sulfatiazol (INN)— chebi
sulfathiazol (INN)— chebi
sulfathiazolum (INN)— chebi
4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide (EXACT_SYNONYM)— chebi
2-(Sulfanilylamino)thiazole (EXACT_SYNONYM)— chebi
2-(p-Aminobenzenesulfonamido)thiazole (EXACT_SYNONYM)— chebi
2-(p-Aminobenzenesulphonamido)thiazole (EXACT_SYNONYM)— chebi
2-Sulfanilamidothiazol (EXACT_SYNONYM)— chebi
2-Sulfanilamidothiazole (EXACT_SYNONYM)— chebi
2-Sulfonamidothiazole (EXACT_SYNONYM)— chebi
4-Amino-N-2-thiazolylbenzenesulfonamide (EXACT_SYNONYM)— chebi
N1-2-Thiazolylsulfanilamide (EXACT_SYNONYM)— chebi
Sulfanilamidothiazole (EXACT_SYNONYM)— chebi
Sulphathiazole (EXACT_SYNONYM)— chebi
sulfthiazole (EXACT_SYNONYM)— chebi

Cross-references

Equivalent identifiers for this same structure in other resources.

cas:72-14-0
drugbank:DB06147
drugcentral:2527
gmelin:218965
hmdb:HMDB0015619
kegg.compound:C11169
kegg.drug:D01047
lincs.smallmolecule:LSM-5327
patent:GB517272
patent:US2362087
patent:US4665100
reaxys:226178
wikipedia.en:Sulfathiazole

Activity roles

Every antimicrobial role a source asserts for this compound — the unreduced evidence behind its antimicrobial_class.

CHEBI:33281 CHEBI:33281

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record
Source	Native ID	Label	Minted CURIE	Version
CHEBI	`CHEBI:9337`	sulfathiazole	`antibioticmech:chebi-8d169bfa8d`	2026-08-30

Mechanism summary

Mode of action: FOLATE_PATHWAY_INHIBITION microbial target — Assigned from ChEBI role CHEBI:50502 (EC 2.5.1.15 (dihydropteroate synthase) inhibitor). ChEBI asserts the role on the compound. The role names a target specific to the microbe or virus — see mode_of_action_target_scope. Not a curator's mechanistic review.

Curation history

SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Seeded from data/raw/ inventories (CHEBI)
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories
RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources
Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.