AntibioticMech

tacrolimus

antibioticmech:aro-2e3b34cc67 ·ANTIMICROBIAL_UNSPECIFIED ·MINTED SEEDED

tacrolimus is an immunosuppressive agent that inhibits calcineurin. This mechanism has been explored for treatment of certain fungal infections, especially mucor species. — PMID:31537789

Classification

antibiotic without defined classificationARO:3000003

Strictly broader compounds or drug classes this molecule belongs to.

• ARO:3000003 ARO:3000003

Chemical structure

Computed structure properties

Molecular formula	C44H69NO12
Charge	0
Average mass	804.0 Da
Monoisotopic mass	803.48197664 Da
Source	PubChem · retrieved 2026-08-29
InChIKey	QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES

C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC

InChI

InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

Cross-references

Equivalent identifiers for this same structure in other resources.

• ARO:3009353
• cas:104987-11-3
• chembl:CHEMBL269732
• pubchem.compound:445643

Source concepts

Every upstream concept that resolved to this record. The merge is the product: this is what shows ChEBI and CARD are describing the same structure.

Upstream concepts merged into this record

Source	Native ID	Label	Minted CURIE	Version
ARO	ARO:3009353	tacrolimus	antibioticmech:aro-2e3b34cc67	2026-08-30

Resistance mechanisms

2 known routes by which microbes resist this compound, grounded in ARO where CARD models them. Grouped by mechanism type — expand a group to see its determinants.

ANTIBIOTIC_EFFLUX 1

ANTIBIOTIC_EFFLUX

Determinant	ARO ID	Organism	Gene families	Evidence
Candida albicans CDR1 with mutations conferring resistance to tacrolimus	ARO:3009437	not organism-specific	—	ARO:3009437 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009353 (tacrolimus); database assertion, not a primary citation.)

UNKNOWN 1

UNKNOWN

Determinant	ARO ID	Organism	Gene families	Evidence
Mucor circinelloides BycA with mutations conferring resistance against tacrolimus	ARO:3009352	not organism-specific	—	ARO:3009352 (CARD/ARO asserts confers_resistance_to_antibiotic ARO:3009353 (tacrolimus); database assertion, not a primary citation.)

Curation history

1. SEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Seeded from data/raw/ inventories (ARO)

2. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

3. RESEEDED_FROM_SOURCES 2026-08-30 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

4. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

5. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

6. RESEEDED_FROM_SOURCES 2026-08-31 · seed_from_sources

   Re-seeded from updated data/raw/ inventories

Provenance

Seeded by scripts/seed_from_sources.py from the committed inventories in data/raw/. View the record.