← Cofactor catalogue
Metal ion
cobalt(2+)
CofactorMech:cobalt · CHEBI:48828
cobalt(2+) is represented by the precise ChEBI entity CHEBI:48828. Cofactor roles are chemical-context annotations; ingredient links describe chemical supply and do not establish uptake, bioavailability or a requirement for every organism.
Download source YAML · View source at this revision
Chemical identity evidence
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ChEBI CHEBI:48828 — ChEBI assigns a cofactor, coenzyme or prosthetic-group role to CHEBI:48828.
Source reference · JSON Pointer /roles_classification · Source licence: CC-BY-4.0
Scoped relationships
Provisional links retain upstream ingredient identifiers. Verified links describe the cited source context, not universal organism requirements. Conjugate forms and precursor supply are distinct relationships.
Supplied by · CHEBI:53503
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Cobalt_chloride_hexahydrate.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:53503; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:53503 — The exact source salt or hydrate supplies the chemical component represented by CHEBI:35696; this is a composition relationship.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:35696 — The parent salt contains the metal in oxidation state +2; the resulting ion is CHEBI:48828.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
Supplied by · CHEBI:35696
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Cocl2.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:35696; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:35696 — The source compound contains the metal in oxidation state +2, corresponding to CHEBI:48828; supply does not imply enzyme occupancy.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
Supplied by · CHEBI:53503
PROVISIONAL · mediaingredientmech
The source is a chemically specified salt containing this metal in the +2 oxidation state; supply is chemical composition, not proof of uptake, cellular availability or enzyme occupancy.
Linked source record: data/ingredients/mapped/Cocl2_X_6_H2o.yaml
Source revision: 0529fc6bc065bfa04aba0aed234f6b0cfad6a142
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MIM ingredient identity — The cited ingredient is mapped to CHEBI:53503; this is a compound-identity assertion, not a bioavailability measurement.
Source reference · JSON Pointer /identifier · Source licence: CC-BY-4.0
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ChEBI CHEBI:53503 — The exact source salt or hydrate supplies the chemical component represented by CHEBI:35696; this is a composition relationship.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
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ChEBI CHEBI:35696 — The parent salt contains the metal in oxidation state +2; the resulting ion is CHEBI:48828.
Source reference · JSON Pointer /ontology_relations · Source licence: CC-BY-4.0
Required by · proteintraitsmech:COFACTOR_REQ_CHEBI_48828
VERIFIED · proteintraitsmech
Conceptual requirement coverage: this PTM trait defines the requirement for the same ChEBI chemical. It is not an organism-level or enzyme-level measurement.
Linked source record: data/traits/function/cofactor_requirement/chebi/cobalt-2-chebi48828.yaml
Source revision: 8d08b33cfbee1e9d1c2fdb2211b82b49dd0c8b1f
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PTM cofactor-requirement concept — The target is a CLASS trait with an explicit cross-reference to this chemical, rather than a measured protein observation.
Source reference · JSON Pointer /xrefs · Source licence: CC-BY-4.0
Used by · MetaCyc:PWY-8130
VERIFIED · pathwaymech
PathwayMech edge ald2-alternative-cobalt records UniProtKB:Q2RXI1 has_cofactor CHEBI:48828. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The cobalt evidence is an alternative in vitro reconstitution of recombinant Rhodospirillum rubrum Ald2, not established physiological occupancy or simultaneous cobalt/nickel dependence.
Linked source record: data/pathways/5-prime-deoxyadenosine-degradation-i.yaml
Source revision: 9584009d49579267233124f4a1057b9425a007d9
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PathwayMech reaction or cofactor edge — PathwayMech edge ald2-alternative-cobalt records UniProtKB:Q2RXI1 has_cofactor CHEBI:48828. This is a cross-reference to the source-scoped reaction or cofactor annotation, not proof of complete pathway flux. The cobalt evidence is an alternative in vitro reconstitution of recombinant Rhodospirillum rubrum Ald2, not established physiological occupancy or simultaneous cobalt/nickel dependence.
Source reference · JSON Pointer /mechanistic_edges/19 · Source licence: CC-BY-4.0
Research gaps
- proteintraitsmech: The curated PTM link covers a cofactor-requirement concept only. A separately sourced, named enzyme exemplar requiring this exact chemical has not been curated in this seed record.