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Altered Schaedler Flora Gnotobiotic Mouse Community

Community ID CommunityMech:000144
Ecological State ENGINEERED
Environment gnotobiotic mouse gastrointestinal tract
ENVO:0001998

The altered Schaedler flora (ASF) is an eight-member defined murine gut bacterial community used in gnotobiotic mice. The community was developed as a standardized, culturable intestinal flora from mouse-derived bacteria and has been used for decades to study host-microbiota relationships, member stability, spatial distribution, immune effects, and genome-informed community metabolism.

Taxonomy

Taxon Ontology ID Functional Roles Abundance
ASF Firmicutes members NCBITaxon:1239
PRIMARY_DEGRADER SECONDARY_FERMENTER
N/A
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF356 Clostridium sp."
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF500 Firmicutes bacterium"
ASF Lactobacillus members NCBITaxon:1578
PRIMARY_DEGRADER
N/A
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF360 Lactobacillus sp."
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF361 Lactobacillus murinus"
Mucispirillum schaedleri ASF457 NCBITaxon:1379858
SECONDARY_FERMENTER
N/A
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF457 Mucispirillum schaedleri"
Parabacteroides ASF519 NCBITaxon:516255
PRIMARY_DEGRADER
N/A
  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "ASF519 Parabacteroides sp."

Ecological Interactions

Ecological interaction network for Altered Schaedler Flora Gnotobiotic Mouse Community Bipartite graph where circle nodes represent taxa and colored rectangles represent ecological interactions (cross-feeding, mutualism, syntrophy, competition, commensalism).
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation

Stable Defined Murine Gut Colonization

COLONIZATION_FACILITATION

Evidence

  • PMID:26323627 - SUPPORT (IN_VIVO)
    "stably passed through multiple generations"

Host-Microbiota Mutualistic Model

MUTUALISM

Evidence

  • PMID:26323627 - SUPPORT (REVIEW)
    "The gastrointestinal (GI) microbiota forms a mutualistic relationship with the host"

Genome-Enabled Member Interaction Model

NICHE_PARTITIONING

Evidence

  • PMID:24723722 - SUPPORT (COMPUTATIONAL)
    "We report here the draft genome sequences of the 8 bacteria that comprise the ASF"

Associated Datasets

Dataset Type Repository Accession
Altered Schaedler Flora draft genome assemblies
Draft genome assemblies for the eight ASF members, including AQFQ00000000.1, AQFR00000000.1, AQFS00000000.1, AYGZ00000000.1, AQFT00000000.1, AYJP00000000.1, AQFU00000000.1, and AQFV00000000.1. 		GENOME OTHER ASF-genome-accessions-AQFQ-AQFV-AYGZ-AYJP

Environmental Factors

Factor Value Unit
gnotobiotic mouse gastrointestinal tract Defined flora maintained in gnotobiotic mice N/A
  • PMID:26323627 - SUPPORT (IN_VIVO)
    "mice colonized with a consortium of known bacteria that naturally inhabit the murine gut"
anaerobic gut community members Culturable mouse-derived intestinal bacteria N/A
  • PMID:26323627 - SUPPORT (REVIEW)
    "were all derived from mice, can be cultured in vitro"