BioModels MODEL2209060002 D pigrum - S aureus Community

Community ID CommunityMech:000010

Ecological State ENGINEERED

Environment laboratory environment
ENVO:01001405

BioModels record MODEL2209060002 is a community GEM combining Dolosigranulum pigrum and Staphylococcus aureus to emulate interactions in a human nasal-like environment.

Taxonomy

Taxon	Ontology ID	Functional Roles	Abundance
Dolosigranulum pigrum	NCBITaxon:29394	CROSS_FEEDER	N/A
Staphylococcus aureus	NCBITaxon:1280	CROSS_FEEDER	N/A

Ecological Interactions

Taxon

Cross-feeding

Mutualism

Syntrophy

Competition

Commensalism

D. pigrum Competitive Exclusion of S. aureus

COMPETITION

Source Taxon: Dolosigranulum pigrum

Target Taxon: Staphylococcus aureus

Metabolites: lactate (CHEBI:422)

Evidence

doi:10.3389/fcimb.2022.925215 - SUPPORT (COMPUTATIONAL)

"Multiple epidemiological studies identify Dolosigranulum pigrum as a likely beneficial bacterium based on its positive association with health, including negative associations with S. aureus."
doi:10.3389/fcimb.2022.925215 - SUPPORT (COMPUTATIONAL)

"By this, we identify and characterize metabolic exchange factors involved in a specific interaction between D. pigrum and S. aureus as an in silico candidate factor for a deep insight into the associated species."
doi:10.3389/fcimb.2022.925215 - SUPPORT (COMPUTATIONAL)

"Its direct application suggests new ways to prevent disease-causing infections by inhibiting the growth of pathogens such as S. aureus through microbe–microbe interactions."

Associated Datasets

Dataset	Type	Repository	Accession
BioModels model file SBML community model combining D. pigrum and S. aureus.	OTHER	OTHER	SA_DP_community.xml
Primary publication Community GEM and use-case for nasal microbiome-relevant interaction modeling.	OTHER	OTHER	doi:10.3389/fcimb.2022.925215