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CRC Fusobacterium Control SynCom

Community ID CommunityMech:000128
Ecological State ENGINEERED
Environment colorectal gut microbiome
UBERON:0001155

A bottom-up designed seven-species synthetic microbial community for ecological control of Fusobacterium nucleatum-associated colorectal cancer models.

Taxonomy

Taxon Ontology ID Functional Roles Abundance
seven commensal bacterial SynCom members NCBITaxon:2
CROSS_FEEDER
N/A
  • PMID:40433987 - SUPPORT (IN_VIVO)
    "A synthetic microbial community (SynCom) is then designed by metabolic network reconstruction, and its performance is validated using coculture experiments and an AOM-DSS induced mouse CRC model."

Ecological Interactions

Ecological interaction network for CRC Fusobacterium Control SynCom Bipartite graph where circle nodes represent taxa and colored rectangles represent ecological interactions (cross-feeding, mutualism, syntrophy, competition, commensalism).
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation

Fusobacterium Ecological Suppression

COMPETITION

Evidence

  • PMID:40433987 - SUPPORT (IN_VIVO)
    "A synthetic microbial community (SynCom) is then designed by metabolic network reconstruction, and its performance is validated using coculture experiments and an AOM-DSS induced mouse CRC model."

Environmental Factors

Factor Value Unit
metabolic network reconstruction design A seven-species SynCom with low competitive interrelationships was designed from human metagenome and metabolomics data. N/A
  • PMID:40433987 - SUPPORT (IN_VIVO)
    "A synthetic microbial community (SynCom) is then designed by metabolic network reconstruction, and its performance is validated using coculture experiments and an AOM-DSS induced mouse CRC model."