← Back to Communities

OMM12 Gnotobiotic Mouse Gut Community

Community ID CommunityMech:000133
Ecological State ENGINEERED
Environment mouse intestine
UBERON:0000160

OMM12, also called Oligo-MM12 or Oligo-Mouse-Microbiota, is a defined 12-strain murine intestinal bacterial community used to colonize germ-free mice for reproducible microbiome research. The community includes Lactobacillus reuteri I49, Enterococcus faecalis KB1, Blautia coccoides YL58, Clostridium innocuum I46, Flavonifractor plautii YL31, Clostridium clostridioforme YL32, Acutalibacter muris KB18, Bacteroides caecimuris I48, Muribaculum intestinale YL27, Bifidobacterium longum subsp. animalis YL2, Akkermansia muciniphila YL44, and Turicimonas muris YL45. It is used as a reduced, genome-characterized model of the mouse gut microbiota for colonization resistance, mucosal immunology, microbial ecology, host-microbiome metabolic cross-talk, and facility-to-facility reproducibility studies.

Taxonomy

Taxon Ontology ID Functional Roles Abundance
OMM12 bacterial strain consortium NCBITaxon:2
CROSS_FEEDER
N/A
  • PMID:29051233 - SUPPORT (IN_VITRO)
    "The Oligo-Mouse-Microbiota (Oligo-MM12) is a community of 12 mouse intestinal bacteria"
  • PMID:31998276 - SUPPORT (IN_VIVO)
    "Lactobacillus reuteri I49, Enterococcus faecalis KB1, Blautia coccoides YL58"

Ecological Interactions

Ecological interaction network for OMM12 Gnotobiotic Mouse Gut Community Bipartite graph where circle nodes represent taxa and colored rectangles represent ecological interactions (cross-feeding, mutualism, syntrophy, competition, commensalism).
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation

Colonization Resistance Against Salmonella

COMPETITION

Biological Processes:

  • interspecies interaction between organisms (GO:0044419)

Evidence

  • PMID:27869789 - SUPPORT (IN_VIVO)
    "confers colonization resistance against Salmonella enterica serovar Typhimurium"

Reproducible Multi-Strain Intestinal Colonization

COLONIZATION_FACILITATION

Biological Processes:

Evidence

  • PMID:31998276 - SUPPORT (IN_VIVO)
    "established in several germ-free mouse facilities world-wide"
  • PMID:31998276 - SUPPORT (IN_VIVO)
    "Absolute abundance of each strain was determined by a strain-specific qPCR assay"

Associated Datasets

Dataset Type Repository Accession
Oligo-MM12 whole-genome sequence resource
Genome announcement reporting high-quality whole-genome sequences for the Oligo-MM12 strains. 		GENOME OTHER PMID:29051233

Environmental Factors

Factor Value Unit
Germ-free mouse host Axenic mice colonized with OMM12 N/A
  • PMID:29051233 - SUPPORT (IN_VIVO)
    "to be used for microbiome research in gnotobiotic mice"
Facility reproducibility Multiple germ-free mouse facilities N/A
  • PMID:31998276 - SUPPORT (IN_VIVO)
    "established in several germ-free mouse facilities world-wide"