A complex defined human gut microbiome assembled from hCom1 and iteratively augmented after fecal challenge to improve stability and colonization resistance in gnotobiotic mice.
Taxonomy
| Taxon | Ontology ID | Functional Roles | Abundance |
|---|---|---|---|
| defined human gut bacterial members | NCBITaxon:2 |
CROSS_FEEDER
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N/A |
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Ecological Interactions
Taxon
Cross-feeding
Mutualism
Syntrophy
Competition
Commensalism
Niche partitioning
Colonization facilitation
Strain competition
Predation
Gut Niche Filling and Colonization Resistance
COLONIZATION_FACILITATIONEvidence
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PMID:36070752 - SUPPORT (IN_VIVO)"We identified new species that engrafted following fecal challenge and added them to hCom1, yielding hCom2."
Environmental Factors
| Factor | Value | Unit |
|---|---|---|
| gnotobiotic fecal challenge | Germ-free mice colonized with hCom1 were challenged with a human fecal sample to identify additional engrafting species. | N/A |
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