DUFMech

All families / PF00672

PF00672: HAMP

HAMP domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF00672: HAMP domain
IPR003660: integrated entry for HAMP domain

Source description

No description supplied.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

47 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A0A0H2Z7X0Diguanylate cyclase TpbB
Pseudomonas aeruginosa (strain UCBPP-PA14)		435 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A0A0H3GPN8Sensor histidine kinase CpxA
Klebsiella pneumoniae subsp. pneumoniae (strain HS11286)		453 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A0A384J5Y1histidine kinase
Botrytis cinerea (strain B05.10)		1315 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
A7F519histidine kinase
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)		1309 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
C0SP89Putative methyl-accepting chemotaxis protein YoaH
Bacillus subtilis (strain 168)		561 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
7 sibling references
G3XD24Methyl-accepting chemotaxis protein PctA
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)		629 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
O32239Putative sensory transducer protein YvaQ
Bacillus subtilis (strain 168)		566 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
O34206Alginate biosynthesis sensor protein KinB
Pseudomonas aeruginosa		595 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P02942Methyl-accepting chemotaxis protein I
Escherichia coli (strain K12)		551 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references
P05704Methyl-accepting chemotaxis protein III
Escherichia coli (strain K12)		546 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
257,581
matches
287,608
proteomes
18,718
taxa
27,652
structures
46
alphafold models
151,473
domain architectures
3,947

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF00672.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.