DUFMech

All families / PF00892

PF00892: EamA

EamA-like transporter family

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF00892: EamA-like transporter family
IPR000620: integrated entry for EamA-like transporter family

Source description

This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

23 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
F4I5D5WAT1-related protein At1g70260
Arabidopsis thaliana		375 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
O31859Uncharacterized transporter YojE
Bacillus subtilis (strain 168)		298 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
O80638WAT1-related protein At2g39510
Arabidopsis thaliana		374 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P0AA67Threonine/homoserine exporter RhtA
Escherichia coli (strain K12)		295 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
7 sibling references
P0AA70Uncharacterized inner membrane transporter YedA
Escherichia coli (strain K12)		306 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
P0ABT8Probable cystine transporter YijE
Escherichia coli (strain K12)		301 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
P0ADP5Biotin transporter
Escherichia coli (strain K12)		299 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P27844Protein RarD
Escherichia coli (strain K12)		296 aa; version 2
UniProt 2026_03		UNIPROT FETCH
2 sibling references
P31125Probable amino-acid metabolite efflux pump
Escherichia coli (strain K12)		299 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
P31437Uncharacterized inner membrane transporter YicL
Escherichia coli (strain K12)		307 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
219,191
matches
383,832
proteomes
21,278
taxa
34,197
structures
3
alphafold models
143,070
domain architectures
602

Classification basis

description says unknown function; pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF00892.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.