DUFMech

All families / PF01549

PF01549: ShK

ShK domain-like

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF01549: ShK domain-like
IPR003582: integrated entry for ShK domain-like

Source description

This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges. The domain is found in the potassium channel inhibitor ShK in sea anemone [InterPro reference PUB00030746][InterPro reference PUB00033687].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

13 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P30652Uncharacterized protein ZK643.6
Caenorhabditis elegans		244 aa; version 3
UniProt 2026_03		UNIPROT FETCH
3 sibling references
P34269Putative tyrosinase-like protein tyr-1
Caenorhabditis elegans		601 aa; version 2
UniProt 2026_03		UNIPROT FETCH
5 sibling references
P55113Zinc metalloproteinase nas-7
Caenorhabditis elegans		382 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references
Q09244Uncharacterized protein C28H8.5
Caenorhabditis elegans		302 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q09662Uncharacterized protein ZK673.1
Caenorhabditis elegans		154 aa; version 2
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q19673Putative tyrosinase-like protein tyr-3
Caenorhabditis elegans		693 aa; version 5
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q20616Peroxidase skpo-1
Caenorhabditis elegans		655 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q21388Zinc metalloproteinase nas-10
Caenorhabditis elegans		540 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q21432Zinc metalloproteinase nas-11
Caenorhabditis elegans		579 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q23490Peroxidase mlt-7
Caenorhabditis elegans		724 aa; version 1
UniProt 2026_03		UNIPROT FETCH
5 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
12,913
matches
26,330
proteomes
1,018
taxa
3,324
structures
10
alphafold models
11,217
domain architectures
1,059

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF01549.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.