All families / PF02687
PF02687: FtsX
FtsX-like permease C-terminal
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF02687: FtsX-like permease C-terminal
IPR003838: integrated entry for FtsX-like permease C-terminal
Source description
This entry represents the C-terminal helices found in members of the ABC type 3 transporter family of permeases, including Cell division protein FtsX from Gram-negative and Gram-positive bacteria [InterPro reference PUB00096431], Permease protein MacB [InterPro reference PUB00072503], Lipoprotein-releasing system transmembrane protein LolC (P57382 (UniProtKB protein)) which has been shown to transport lipids targeted to the outer membrane across the inner membrane [InterPro reference PUB00071889]. This region contains three transmembrane helices.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
16 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O06981 | Uncharacterized ABC transporter permease YvcS Bacillus subtilis (strain 168) | 646 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O31712 | Uncharacterized ABC transporter permease YknZ Bacillus subtilis (strain 168) | 397 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| O34741 | Bacitracin export permease protein BceB Bacillus subtilis (strain 168) | 646 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR2 sibling references |
| O34876 | Cell division protein FtsX Bacillus subtilis (strain 168) | 296 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| O35005 | ABC transporter permease YtrF Bacillus subtilis (strain 168) | 436 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| P0AC30 | Cell division protein FtsX Escherichia coli (strain K12) | 352 aa; version 1 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
| P0ADC3 | Lipoprotein-releasing system transmembrane protein LolC Escherichia coli (strain K12) | 399 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR10 sibling references
|
| P42424 | ABC transporter permease protein YxdM Bacillus subtilis (strain 168) | 622 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P46324 | Uncharacterized ABC transporter permease YvrN Bacillus subtilis (strain 168) | 409 aa; version 3 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| P75831 | Macrolide export ATP-binding/permease protein MacB Escherichia coli (strain K12) | 648 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 143,181
- matches
- 194,321
- proteomes
- 18,550
- taxa
- 26,730
- structures
- 72
- alphafold models
- 90,109
- domain architectures
- 129
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.