All families / PF03479
PF03479: PCC
Plants and Prokaryotes Conserved (PCC) domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF03479: Plants and Prokaryotes Conserved (PCC) domain
IPR005175: integrated entry for Plants and Prokaryotes Conserved (PCC) domain
Source description
This is a Plants and Prokaryotes Conserved (PPC) domain found in proteins that contain AT-hook motifs PF02178 (Pfam entry) which strongly suggests a DNA-binding function for the proteins as a whole. Proteins with PPC domains are found in Bacteria, Archaea and the plant kingdom [InterPro reference PUB00074814,InterPro reference PUB00040306].The PPC domain has a single alpha-helix packed against an antiparallel beta-sheet, which is formed by five beta-strands. There are three highly conserved histidine residues, eg at 117, 119 and 133 in Q46QL5 (UniProtKB protein) which appear to form a zinc-binding site, and the domain has been observed to form homotrimers. The domain co-occurs with a thioredoxin-like domain in uncharacterized cyanobacterial proteins [InterPro reference PUB00040306].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O22130 | AT-hook motif nuclear-localized protein 22 Arabidopsis thaliana | 317 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| O82166 | AT-hook motif nuclear-localized protein 21 Arabidopsis thaliana | 285 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8GWQ2 | AT-hook motif nuclear-localized protein 20 Arabidopsis thaliana | 281 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8VYJ2 | AT-hook motif nuclear-localized protein 1 Arabidopsis thaliana | 356 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9C9K7 | AT-hook motif nuclear-localized protein 29 Arabidopsis thaliana | 302 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9S7C9 | AT-hook motif nuclear-localized protein 27 Arabidopsis thaliana | 311 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9SJG4 | AT-hook motif nuclear-localized protein 16 Arabidopsis thaliana | 257 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9SR17 | AT-hook motif nuclear-localized protein 19 Arabidopsis thaliana | 315 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 19,177
- matches
- 19,300
- proteomes
- 3,910
- taxa
- 7,806
- structures
- 7
- alphafold models
- 15,108
- domain architectures
- 165
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.