DUFMech

All families / PF03759

PF03759: PRONE

PRONE (Plant-specific Rop nucleotide exchanger)

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF03759: PRONE (Plant-specific Rop nucleotide exchanger)
IPR005512: integrated entry for PRONE (Plant-specific Rop nucleotide exchanger)

Source description

This is a functional guanine exchange factor (GEF) of plant Rho GTPase [InterPro reference PUB00043712].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

11 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A4IJ27Rop guanine nucleotide exchange factor 3
Arabidopsis thaliana		473 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
5 sibling references
F4J1G1Rop guanine nucleotide exchange factor 13
Arabidopsis thaliana		576 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q0WNP7Rop guanine nucleotide exchange factor 4
Arabidopsis thaliana		463 aa; version 1
UniProt 2026_03		UNIPROT FETCH
5 sibling references
Q1KS66Rop guanine nucleotide exchange factor 10
Arabidopsis thaliana		493 aa; version 1
UniProt 2026_03		UNIPROT FETCH
5 sibling references
Q56WM6Rop guanine nucleotide exchange factor 14
Arabidopsis thaliana		576 aa; version 1
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q93ZY2Rop guanine nucleotide exchange factor 1
Arabidopsis thaliana		548 aa; version 2
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q9CA89Rop guanine nucleotide exchange factor 12
Arabidopsis thaliana		515 aa; version 1
UniProt 2026_03		UNIPROT FETCH
5 sibling references
Q9LV40Rho guanine nucleotide exchange factor 8
Arabidopsis thaliana		523 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9LZN0Rop guanine nucleotide exchange factor 7
Arabidopsis thaliana		546 aa; version 1
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q9M811Rop guanine nucleotide exchange factor 11
Arabidopsis thaliana		543 aa; version 2
UniProt 2026_03		UNIPROT FETCH
5 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
6,408
matches
6,879
proteomes
396
taxa
1,109
structures
3
alphafold models
5,112
domain architectures
84

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF03759.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.