DUFMech

All families / PF04776

PF04776: protein_MS5

Protein MS5

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF04776: Protein MS5
IPR006462: integrated entry for Protein MS5

Source description

Proteins are known only from species of Brassicaceae. Protein MS5 is essential for pairing of homologues during early prophase stage of meiosis but not necessary for the initiation of DNA double-strand breaks.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

13 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O49698UPF0725 protein At4g17990
Arabidopsis thaliana		233 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P0C8P5UPF0725 protein At1g19565
Arabidopsis thaliana		214 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q5BPN1UPF0725 protein At3g57210
Arabidopsis thaliana		158 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
Q5BPP4UPF0725 protein At3g44770
Arabidopsis thaliana		318 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q84J62UPF0725 protein At2g19200
Arabidopsis thaliana		169 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8LFV1UPF0725 protein At4g29550
Arabidopsis thaliana		358 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8S8D8UPF0725 protein At2g20625
Arabidopsis thaliana		190 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q94A88UPF0725 protein At1g23970
Arabidopsis thaliana		378 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9C6N2UPF0725 protein At1g27860
Arabidopsis thaliana		289 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9FN07UPF0725 protein At5g63820
Arabidopsis thaliana		225 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,203
matches
1,257
proteomes
24
taxa
63
structures
1
alphafold models
881
domain architectures
57

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04776.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.