DUFMech

All families / PF04829

PF04829: PT-VENN

Pre-toxin domain with VENN motif

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF04829: Pre-toxin domain with VENN motif
IPR006914: integrated entry for Pre-toxin domain with VENN motif

Source description

This family represents a conserved region found in many bacterial porlymorphic toxins which is located before the C-terminal toxin modules [InterPro reference PUB00057479][InterPro reference PUB00057480].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

9 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A0A0H3B0B8Deoxyribonuclease CdiA
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)		1077 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
A0A1S4NYE3tRNA nuclease CdiA
Escherichia coli (strain STEC_O31)		3253 aa; version 2
UniProt 2026_03		UNIPROT FETCH
2 sibling references
B3BM80Deoxyribonuclease CdiA-o11
Escherichia coli O157:H7 (strain EC869)		377 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
C4SGN7tRNA nuclease CdiA
Yersinia mollaretii (strain ATCC 43969 / DSM 18520 / CIP 103324 / CNY 7263 / WAIP 204)		2963 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
D5CBA016S rRNA endonuclease CdiA
Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56)		3321 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
E0SDG8Deoxyribonuclease CdiA
Dickeya dadantii (strain 3937)		3326 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P0DSI1tRNA nuclease CdiA
Escherichia coli (strain NC101)		3289 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q0T963tRNA nuclease CdiA
Escherichia coli O6:K15:H31 (strain 536 / UPEC)		3242 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q7CGD9Toxin CdiA
Yersinia pestis		3295 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,423
matches
1,424
proteomes
608
taxa
1,023
structures
0
alphafold models
497
domain architectures
413

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04829.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.