All families / PF04852
PF04852: ALOG_dom
ALOG domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF04852: ALOG domain
IPR006936: integrated entry for ALOG domain
Source description
The 125-residue ALOG (Arabidopsis LSH1 and oryza G1) domain is rich in basic amino acids, especially arginine, and is highly conserved among land plants. Members of the ALOG family of proteins function as key developmental regulators. It has been proposed that the ALOG domain originated from the N-terminal DNA-binding domains of integrases belonging to the tyrosine recombinase superfamily encoded by a distinct type of DIRS1-like LTR retrotransposon found in several eukaryotes. Secondary structure predictions revealed an all-alpha helical domain with four conserved helices [InterPro reference PUB00072583,InterPro reference PUB00072584]. Some proteins known to contain an ALOG domain are Arabidopsis thaliana LIGHT_DEPENDENT SHORT HYPOCOTYLS1 (LSH1),involved in phytochrome- dependent light signalling; Oryza G1, involved in the specification of sterile lemma identity and Plant defence proteins.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
10 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O82268 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 3 Arabidopsis thaliana | 219 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q6K5X1 | Protein G1-like6 Oryza sativa subsp. japonica | 248 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q6NNI3 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 1 Arabidopsis thaliana | 190 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8GVZ6 | Protein G1 Oryza sativa subsp. japonica | 276 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9FGH2 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 5 Arabidopsis thaliana | 182 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9FZ51 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8 Arabidopsis thaliana | 164 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9LMK2 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 6 Arabidopsis thaliana | 196 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9LW68 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 4 Arabidopsis thaliana | 195 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9M836 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 2 Arabidopsis thaliana | 201 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9S7R3 | Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 10 Arabidopsis thaliana | 177 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 5,640
- matches
- 5,680
- proteomes
- 401
- taxa
- 1,160
- structures
- 1
- alphafold models
- 4,513
- domain architectures
- 68
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.