PF05093: CIAPIN1

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF05093: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
IPR046408: integrated entry for Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

Source description

Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [InterPro reference PUB00055951]. CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [InterPro reference PUB00055952]. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress [InterPro reference PUB00109169]. These proteins consist of two domains, the N-terminal well-folded one, with a S-adenosylmethionine methyltransferase-like fold and the C-terminal more flexible domain, represented in this entry, which contains two highly conserved cysteine rich motifs that bind Fe-S clusters [InterPro reference PUB00067100,InterPro reference PUB00056284].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

10 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
A1D3K3	Fe-S cluster assembly protein dre2 Aspergillus fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	320 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF16803
A3LQZ8	Fe-S cluster assembly protein DRE2 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	359 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF16803
C0H4X5	Anamorsin homolog Plasmodium falciparum (isolate 3D7)	266 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: InterPro:IPR046408
P36152	Fe-S cluster assembly protein DRE2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	348 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 7 sibling references ProteinTraitsMech: GO:1901299 ProteinTraitsMech: InterPro:IPR046408 ProteinTraitsMech: InterPro:IPR031838 ProteinTraitsMech: Pfam:PF05093 ProteinTraitsMech: Pfam:PF16803 ProteinTraitsMech: CATH:3.40.50.11000 ProteinTraitsMech: UniProtKB:P36152
P41847	Anamorsin homolog Caenorhabditis elegans	238 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: InterPro:IPR046408
Q6AZB3	Anamorsin Danio rerio	311 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF20922
Q6FI81	Anamorsin Homo sapiens	312 aa; version 2 UniProt 2026_03	UNIPROT FETCH 4 sibling references ProteinTraitsMech: InterPro:IPR046408 ProteinTraitsMech: InterPro:IPR049011 ProteinTraitsMech: Pfam:PF20922 ProteinTraitsMech: Pfam:PF05093
Q8L7Z3	Anamorsin homolog Arabidopsis thaliana	272 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR046408 ProteinTraitsMech: Pfam:PF05093
Q8WTY4	Anamorsin Mus musculus	309 aa; version 1 UniProt 2026_03	UNIPROT FETCH 4 sibling references ProteinTraitsMech: GO:0097361 ProteinTraitsMech: InterPro:IPR046408 ProteinTraitsMech: InterPro:IPR049011 ProteinTraitsMech: Pfam:PF20922
Q9V3Y2	Anamorsin homolog Drosophila melanogaster	248 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR046408 ProteinTraitsMech: InterPro:IPR049011

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 4,152
matches: 4,936
proteomes: 3,289
taxa: 8,763
structures: 0
alphafold models: 3,590
domain architectures: 90

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF05093.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.