All families / PF06722
PF06722: EryCIII-like_C
Erythromycin biosynthesis protein CIII-like, C-terminal domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF06722: Erythromycin biosynthesis protein CIII-like, C-terminal domain
IPR010610: integrated entry for Erythromycin biosynthesis protein CIII-like, C-terminal domain
Source description
This domain is found at the C-terminal of Erythromycin biosynthesis protein CIII (EryCIII) from Saccharopolyspora erythraea and similar proteins found in bacteria and eukaryotes. This protein is organised into two domains, both of them with a Rossmann-like alpha/beta fold. The C-terminal domain contains the nucleotide disphospho-sugar (NDP-sugar) binding site [InterPro reference PUB00074327].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
22 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A0A0H2V630 | Enterobactin C-glucosyltransferase Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 371 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| A4F7P3 | 3-alpha-mycarosylerythronolide B desosaminyl transferase Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) | 421 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O05496 | Uncharacterized UDP-glucosyltransferase YdhE Bacillus subtilis (strain 168) | 395 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| O31853 | Uncharacterized UDP-glucosyltransferase YojK Bacillus subtilis (strain 168) | 405 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| O34539 | NDP-glycosyltransferase YjiC Bacillus subtilis (strain 168) | 392 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| O68841 | Glycosyltransferase OleI Streptomyces antibioticus | 424 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q06321 | Sterol 3-beta-glucosyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 1198 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q194P6 | Glycosyltransferase Streptomyces argillaceus | 379 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q194P9 | Glycosyltransferase Streptomyces argillaceus | 396 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q194Q0 | Glycosyltransferase Streptomyces argillaceus | 407 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 25,744
- matches
- 25,805
- proteomes
- 7,523
- taxa
- 12,630
- structures
- 57
- alphafold models
- 15,860
- domain architectures
- 290
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.