PF07717: OB_NTP_bind

Oligonucleotide/oligosaccharide-binding (OB)-fold

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF07717: Oligonucleotide/oligosaccharide-binding (OB)-fold
IPR011709: integrated entry for Oligonucleotide/oligosaccharide-binding (OB)-fold

Source description

This family is found towards the C-terminus of the DEAD-box helicases (PF00270 (Pfam entry)). In these helicases it is apparently always found in association with PF04408 (Pfam entry). There do seem to be a couple of instances where it occurs by itself - e.g. Q84VZ2 (UniProtKB protein). The structure PDB:3i4u adopts an OB-fold. helicases (PF00270 (Pfam entry)). In these helicases it is apparently always found in association with PF04408 (Pfam entry). This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins [InterPro reference PUB00092307].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

29 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
A3KMI0	ATP-dependent RNA helicase dhx29 Xenopus laevis	1362 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF24385
F4HYJ7	DExH-box ATP-dependent RNA helicase DExH3 Arabidopsis thaliana	1197 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF27261
F4ILR7	DExH-box ATP-dependent RNA helicase DExH1 Arabidopsis thaliana	995 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF27261
F4IM84	DExH-box ATP-dependent RNA helicase DExH5, mitochondrial Arabidopsis thaliana	1113 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF27261
F4K2E9	Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 Arabidopsis thaliana	1255 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 2 sibling references ProteinTraitsMech: Pfam:PF07717 ProteinTraitsMech: UniProtKB:F4K2E9
F4KGU4	ATP-dependent RNA helicase DEAH12, chloroplastic Arabidopsis thaliana	1775 aa; version 1 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: Pfam:PF24638 ProteinTraitsMech: Pfam:PF24641 ProteinTraitsMech: Pfam:PF24471
O43143	ATP-dependent RNA helicase DHX15 Homo sapiens	795 aa; version 2 UniProt 2026_03	PTM REGISTRY MIRROR 4 sibling references ProteinTraitsMech: Pfam:PF00270 ProteinTraitsMech: Pfam:PF00271 ProteinTraitsMech: PROSITE:PS00690 ProteinTraitsMech: UniProtKB:O43143
O46072	Probable ATP-dependent RNA helicase kurz Drosophila melanogaster	1192 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF23362
O60231	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 Homo sapiens	1041 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF21010
O70133	ATP-dependent RNA helicase A Mus musculus	1380 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF07717

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 55,636
matches: 55,670
proteomes: 11,620
taxa: 19,634
structures: 160
alphafold models: 34,331
domain architectures: 1,449

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF07717.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.